Preheat the oven to 350° and line a baking sheet with a silicone baking mat, parchment paper or grease it.
Roll out one can of crescent dough on the baking sheet and pinch the seems together if needed.
Spread the pizza sauce on the crescent dough leaving about 1/4 inch clean around the edges.
Sprinkle half of the cheese over the sauce. Spread the pepperonis over the cheese. Sprinkle the remaining cheese over the pepperonis.
Roll the other can of dough out over the cheese. Pinch the edges together all the way around.
In a small bowl, combine the melted butter, garlic powder and Italian seasoning. Brush this mixture over the crescent dough. Bake the in the preheated oven for approximately 20 minutes.